Metabolic Disorder, Cardiovascular, and Aging

Conducts research in the field of metabolic disorders, cardiovascular diseases, and physiology of aging, that can be translated into community and global health services, apart from the implementation in Dr. Cipto Mangunkusumo General Hospital and other teaching hospitals. The cluster is also expected to play a role in designation of medical education and health services policies. The research focus on the identification of basic phatomechanism and development of early detection methods including –but not limited to- biomarkers in the field of metabolic, cardiovascular and aging.

Ongoing Research

  • Perubahan ekosistem saluran cerna pada urbanisasi dan dampaknya terhadap diabetes melitus tipe 2: integrasi studi metabolik, nutrisi dan imunologi.
  • Puasa pada Pasien Diabetes Melitus Tipe 2 dan Implikasinya terhadap Stress Metabolik, Hemodinamika, dan Sistem Imun.
  • First Degree Relative DMT2.
  • Jakarta Longitudinal Study of Graves Disease.
  • Athlete’s Heart.
  • Role of Gut Ecosystem in Urbanization and Its Effects on Obesity and Type 2 Diabetes: Comprehensiive Study on Metabolic, Nutrition, and Immunology (2018-2021).
  • The Intestinal Microbiota, Inflammation, and Insulin Resistance across the spectrum of Dysglycemia (2018-2021).
  • Jakarta Longitudinal Grave Disease (2019-2024).
  • Telomere Length in Vascular Aging (2020-2021).
  • Pengaruh Obesitas Sarkopenia Pada Penyandang Diabetes Mellitus Tipe 2: Kajian Terhadap Parameter Metabolik, Kardiovaskular dan Hormonal (2020-2021).
  • Gangguan Kardio-Vaskular-Metabolik Dini Pada Populasi First Degree Relatives Diabetes Mellitus Tipe 2 (2020-2021).
  • Peningkatan Kendali Diabetes pada Pasien Diabetes Melitus Tipe-2 di Puskesmas (2020-2021).
  • COVID-19, Aging, And Cardiometabolic Risk Factors (CARAMEL) Study:Integrating Aging, Cardiovascular, Metabolic, and Immunological Studies to Unravel Covid-19 Pathophysiology (2020-2024).


  • Darmowidjojo B, Antika LD. Subclinical Thyroid Dysfunction: Diagnosis and Management. eJournal Kedokteran Indonesia. 2018; 6 (2) : 140-150.
  • Tahapary D, Ruiter K, Kurniawan F, Djuardi Y, Wang Y, Nurdin S, Iskandar E, Minggu D, Yunir E, Guigas B, Supali T, Rensen P, Sartono E, Soewondo P, Harbuwono DS, Smit JWA, Yazdanbakhsh M. Impact Of Rural-Urban Environment on Metabolic Profile and Response to A 5-Day High-Fat Diet. Scientific Reports. 2018; 8 : 8149.
  • Harbuwono DS, Pramono LA, Yunir E, Subekti I. Obesity and Central Obesity in Indonesia: Evidence from a National Health Survey. Medical Journal Of Indonesia. 2018: 27 (2) : 0853-1773.
  • Tahapary DL, de Ruiter K, Martin I, Brienen EAT, van Lieshout L, Djuardi Y, Djimandjaj CC, Houwing-Duistermaat JJ, Soewondo P, Sartono E, Supali T, Smit JWA, Yazdanbakhsh M. Effect of anthelmintic treatment on leptin, adiponectin and leptin to adiponectin ratio: a randomized-controlled trial. Nutrition Diabetes. 2017; 10 (7) : 289.
  • Bachtiar BM, Theodorea CF, Tahapary DL, Astrella C, Natalina, Bachtiar EW.. A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform. F1000Research. 2021; 10: 7.
  • Alkaff FF, Illavi F, Salamah S, Setiyawati W, Ramadhani R, Purwantini E, Tahapary DL. The Impact of the Indonesian Chronic Disease Management Program (PROLANIS) on Metabolic Control and Renal Function of Type 2 Diabetes Mellitus Patients in Primary Care Setting. Journal of Primary Care & Community Health. 2021; 12: 1-10.
  • Leander DJ, Tahapary DL. Pemilihan Obat Antidiabetik Oral pada Pasien Diabetes Melitus Tipe 2 dengan Risiko Tinggi untuk Kejadian Kardiovaskular. Jurnal Penyakit Dalam Indonesia. 2021; 7(4): 240-248.
  • Lazarus G, Audrey J, Wangsaputra VK, Tamara A, Tahapary DL. High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis. Diabetes Research and Clinical Practice. 2021; 171: 108561.
  • Tahapary D, Harbuwono D, Yunir E, Soewondo P. Diagnosing metabolic syndrome in a multi-ethnic country: is an ethnic-specific cut-off point of waist circumference needed?. Nutrition and Diabetes. 2020; 19.
  • Kurniawan F, Tahapary D, Ruiter K, Yunir E, Biermasz N, Smit J, Supali T, Sartono E, Yazdanbakhsh M, Soewondo P. Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia. Scientific Reports. 2020; 10 (1) : 19023.
  • Harbuwono D, Tahapary D, Tarigan T, Yunir E. New proposed cut-off of waist circumference for central obesity as risk factor for diabetes mellitus: Evidence from the Indonesian Basic National Health Survey. PLoS ONE. 2020; 15 (11) : 0242417.
  • Tahapary D, Astrella C, Kristanti M, Harbuwono D, Soewondo P. The impact of Ramadan fasting on metabolic profile among type 2 diabetes mellitus patients: A meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020; 14 (5) : 1559-1570.
  • Tamara A, Tahapary D. Obesity as a predictor for a poor prognosis of COVID-19: A systematic review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020; 14 (4) : 655-659.
  • Fitria AR, Soeroso Y, Natalina , Tahapary DL, Bachtiar BM. Relationship of methyl mercaptan and hydrogen sulfide levels with tannerella forsythia quantity in periodontitis patients with halitosis and diabetes mellitus. International Journal of Applied Pharmaceutics. 2020; 12 : 49-52.
  • Harbuwono D, Kurniawan F, Sudarsono N, Tahapary D. The impact of Ramadan fasting on glucose variability in type 2 diabetes mellitus patients on oral anti diabetic agents. PLoS ONE . 2020; 15 (6) : 0234443.
  • Sigit F, Tahapary D, Trompet S, Sartono E, Dijk K, Rosendaal F, Mutsert R. The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies. Diabetology & Metabolic Syndrome. 2020; 12 : 2.
  • Ruiter K, Jochem P, Tahapary D, Stam K, König M, Unen V, Laban S, Höllt T, Mbow M, Lelieveldt B, Koning F, Sartono E, Smit J, Supali T, Yazdanbakhsh M. Helminth infections drive heterogeneity in human type 2 and regulatory cells. Science Translational Medicine. 2020; 12 (524) : 3703.
  • Nusrianto R, Ayundini G, Kristanti M, Astrella C, Amalina N, Muhadi, Riyadina W, Tahapary DL, Soewondo P. Visceral adiposity index and lipid accumulation product as a predictor of type 2 diabetes mellitus: The Bogor cohort study of non-communicable diseases risk factors. Diabetes Research and Clinical Practice, 2019, 155, 107798.
  • Filantropi D, Yunir E, Prahasary AN, Tahapary DL. Penyakit Arteri Perifer dan Mortalitas Kardiovaskular pada Pasien Diabetes Melitus Tipe-2. Jurnal Ilmu Penyakit. 2019; 6(2).
  • Ayundini G, Astrella C, Tahapary D, Soewondo P. A Systematic Review on the Association between Lipid Accumulation Product Index and Type 2 Diabetes Mellitus. Journal of the ASEAN Federation of Endocrine Societies. 2019; 34 (1) : 16-20.
  • Tarigan T, Khumaedi A, Wafaa S, Johan M, Abdullah M, Surono I, Tahapary D. Determinant of postprandial triglyceride levels in healthy young adults. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019; 13 (3) : 1917-1921.
  • Nusrianto R, Tahapary D, Soewondo P. Visceral adiposity index as a predictor for type 2 diabetes mellitus in Asian population: A systematic review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019; 13 (2) : 1231-1235


  • RSUPN Cipto Mangunkusumo.
  • Sports Medicine.
  • Public Health FKUI.
  • Litbangkes RI.
  • Department of Parasitology, Faculty of Medicine, Universitas Indonesia.
  • Nangapanda Research Center.
  • Harapan Kita National Heart Center.
  • Leiden University Medical Center.
  • Radboud University Medical Centre.
  • DINKES DKI Jakarta.
  • Perkumpulan Endokrinologi Indonesia (PERKENI).
  • Himpunan Studi Obesitas (HISOBI).
  • Persatuan Pembuluh Darah dan Limfe Indonesia (PPI).
  • Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI).
  • Sugar SPIN