Metabolic Disorder, Cardiovascular, and Aging
Conducts research in the field of metabolic disorders, cardiovascular diseases, and physiology of aging, that can be translated into community and global health services, apart from the implementation in Dr. Cipto Mangunkusumo General Hospital and other teaching hospitals. The cluster is also expected to play a role in designation of medical education and health services policies. The research focus on the identification of basic phatomechanism and development of early detection methods including –but not limited to- biomarkers in the field of metabolic, cardiovascular and aging.
Research Projects
- Ramadan fasting in type 2 diabetes*.
- First-degree relatives of type 2 diabetes*.
- Changes in microbiota profile and gut permeability on urbanization*
- Gut microbiome on various spectrum of dysglycaemia.
- Graves’ disease longitudinal study
- Athlete’s heart#.
- Telomere length in vascular aging.
- Heart failure with preserved ejection fraction#.
- Effect of sarcopenic obesity on type 2 diabetes.
- Integration of Health Coaching and Diabetes Education in Type 2 Diabetes Mellitus Management at Primary Health Care* (ClinicalTrials.gov Identifier: NCT05090488).
- COVID-19, aging and cardiometabolic risk factors (CARAMEL) study* (ClinicalTrials.gov Identifier: NCT04802044)
The Bogor cohort study of non-communicable diseases*. - DiabetesLab Project (https://www.diabeteslab.id).
- Genomic Study in type 2 Diabetes.
- Anti-Senescence Drug in Vascular Aging*.
- ID-CALDERA: Indonesia’s Cardiovascular Risk Stratification in Diabetes using Smartphone-based Retinal Imaging (https://caldera.diabeteslab.id/).
- Effectivity and Safety of Stem Cell Therapy in type 2 Diabetes.
- Development of Biological Age Prediction in type 2 Diabetes
* datasets and biobanks are open for further analysis
# upcoming projects, open for collaboration
Publication
- Lifestyle and Clinical Risk Factors in Relation with The Prevalence of Diabetes in The Indonesian Urban and Rural Populations: The 2018 Indonesian Basic Health Survey (https://doi.org/10.1016/j.pmedr.2024.102629).
- Physio-Cognitive Decline Syndrome Among Middle-Aged Diabetes Patients: Handgrip Strength Significantly Correlates with Glycemic Control and Cognitive Score (https://doi.org/10.1016/j.heliyon.2024.e24018).
- The a Systematic Review of the Accuracy of Insulin and C-peptide Secretion Ratios During the Oral Glucose Tolerance Test to Diagnose Insulinoma (https://asean-endocrinejournal.org/index.php/JAFES/article/view/2781).
- The Increase in CD14+CD16+ Monocytes is Correlated with Cardiovascular Disease Risk Marker in Type 2 Diabetes (https://www.inabj.tjahajabaroe.com/index.php/ibj/article/view/2798/694).
- The Impact of COVID-19 Severity on TNF-α and IFN-γ in T2DM Patients’ PBMC Monocytes (https://mki-ojs.idionline.org/jurnal/issue/view/52).
- Altered Body Composition and Cytokine Production in Patients with Elevated HOMA-IR after SARS-CoV-2 Infection: A 12-Month Longitudinal Study (https://www.mdpi.com/2227-9059/12/7/1581).
- Tackling Obesity In Indonesia: Current Problems And Future Directions (https://doi.org/10.13181/mji.ed.247691)
- Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus (https://doi.org/10.1371/journal.pone.0279915).
- Defining the optimum HOMA-IR cut-off value for insulin resistance among ARV-treated HIV patients in Indonesia (https://doi.org/10.1016/j.dsx.2023.102719).
- Simple anthropometric measures to predict visceral adipose tissue area in middle-aged Indonesian men (https://doi.org/10.1371/journal.pone.0280033).
- Impact of the source of hematopoietic stem cells on immune reconstitution after transplantation: A systematic review (https://doi.org/10.1111/ejh.13966).
- Chronic complications risk among type 2 diabetes patients with a family history of diabetes (https://doi.org/10.1002/cdt3.80).
- Prevalence and Associated Factors of Female Sexual Dysfunction among Type 2 Diabetes Patients in Indonesia: A Systematic System Review and Meta-Analysis (https://doi.org/10.1016/j.dsx.2023.102878).
- Reduced Population of CD36-/ABCA1+ Macrophages is Correlated with An Increase of Coronary Artery Disease Risk Markers in Type 2 Diabetes Mellitus (https://doi.org/10.18585/inabj.v15i6.2625).
- Risk Factors of Severe Hypoglycemia Among Patients with Type 2 Diabetes Mellitus in out-patients clinic of tertiary hospital in Indonesia (https://doi.org/10.1038/s41598-023-43459-2)
- The Role of High Fat Diet on Serum Uric Acid Level among Healthy Male First-Degree Relatives of Type 2 Diabetes Mellitus (https://doi.org/10.1038/s41598-023-44843-8)
- Autologous Intraarterial Pancreatic Bone-Marrow Mononuclear Cells Infusion in T2D Patients: Changes on Beta-Cells Function, Insulin Resistance, and Inflammatory Marker (https://www.sciencedirect.com/science/article/abs/pii/S2452318623000612).
- Treatment Adherence and Incidence of Coronary Heart Disease in Type 2 Diabetes Mellitus Patients. DOI: 10.21109/kesmas.v17i2.5453.
- Adherence to the healthy lifestyle guideline in relation to the metabolic syndrome: Analyses from the 2013 and 2018 Indonesian national health surveys. DOI: 10.1016/j.pmedr.2022.101806.
- Effects of Moringa oleifera in Two Independents Formulation and as Neuroprotective Agent Against Scopolamine-Induced Memory Impairment in Mice. DOI: 10.3389/fnut.2022.799127.
- Three Years Survival and Factor Predicting Amputation or Mortality in Patients with High Risk for Diabetic Foot Ulcer in Fatmawati General Hospital, Jakarta. DOI: 10.1177/21501319211063707.
- Characteristics of Diabetic Foot Ulcer Patients Pre- and During COVID-19 Pandemic: Lessons Learnt From a National Referral Hospital in Indonesia. DOI: 10.1177/21501319221089767.
- Association Between Statin Use and Poor Outcomes in COVID-19 Patients with Diabetes Mellitus: A Systematic Review. DOI: 10.2174/1573399818666220209095056.
- Challenges in the diagnosis of insulin resistance: Focusing on the role of HOMA-IR and Tryglyceride/glucose index. https://doi.org/10.1016/j.dsx.2022.102581.
- Urbanization and Unfavorable Changes in Metabolic Profiles: A Prospective Cohort Study of Indonesian Young Adults. https://doi.org/10.3390/nu14163326.
- Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats. https://doi.org/10.3389/fmed.2022.867497
- A review of pathobiological mechanisms and potential application of medicinal plants for vascular aging: focus on endothelial cell senescence https://doi.org/10.13181/mji.rev.226064.
- Sarcopenia and Chronic Complications of Type 2 Diabetes Mellitus (https://doi.org/10.1900/rds.2022.18.157).
- The role of Intestinal-Fatty Acid Binding Proteins and Chitinase-3-Like Protein 1 across the spectrum of dysglycemia (https://doi.org/10.1016/j.dsx.2021.102366).
- The Risk Factors of Inpatient Hypoglycemia in a Tertiary Care Hospital in Indonesia: Running title: Inpatient Hypoglycemia (https://doi.org/10.15605/jafes.037.02.06).
- The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model (https://doi.org/10.2147/jep.s386745)
- The role of Intestinal-Fatty Acid Binding Proteins and Chitinase-3-Like Protein 1 across the spectrum of dysglycemia. DOI: 10.1016/j.dsx.2021.102366.
- Impact of diabetes mellitus on COVID-19 clinical symptoms and mortality: Jakarta’s COVID-19 epidemiological registry. DOI: 10.1016/j.pcd.2021.11.002.
- Adherence to Treatment and Glycemic Control in Patients with Type 2 Diabetes Mellitus: A 4-Year Follow-up PTM Bogor Cohort Study, Indonesia. DOI: 10.2147/PPA.S318790.
- Cardiovascular disease prediction model for Indonesian adult population with prediabetes and diabetes mellitus: The Bogor Cohort study of Noncommunicable Diseases Risk Factors. DOI: 10.1016/j.dsx.2021.102330.
- A cross-sectional study on the telemedicine usage and glycemic status of diabetic patients during the COVID-19 pandemic. DOI: 10.13181/mji.oa.215558.
- Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016). DOI: 10.1016/j.dsx.2021.102280.
- Statin Mencegah Penurunan Kadar Hemoglobin dan Parameter Hematologi Lainnya pada Model Tikus Gagal Ginjal Eksperimental. DOI: 10.28932/jmh.v3i2.3332.
- Non-vascular contributing factors of diabetic foot ulcer severity in national referral hospital of Indonesia. DOI: 10.1007/s40200-021-00827-x.
- The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population. DOI: 10.1016/j.numecd.2021.05.012.
- The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus. DOI: 10.1016/j.heliyon.2021.e06773.
- Immunomodulatory effect of in vitro calcitriol in fit and frail elderly. DOI: 10.1016/j.intimp.2021.107737.
- Puasa Ramadan dan Diabetes Melitus: Risiko, Manfaat dan Peluang Penelitian. DOI: 10.7454/jpdi.v8i1.576.
- A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform. DOI: 10.12688/f1000research.28216.4.
- The Impact of the Indonesian Chronic Disease Management Program (PROLANIS) on Metabolic Control and Renal Function of Type 2 Diabetes Mellitus Patients in Primary Care Setting. DOI: 10.1177/2150132720984409
- Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients. DOI: 10.15283/ijsc20088.
- High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis. DOI: 10.1016/j.diabres.2020.10856.
- Burden of metabolic diseases in indonesia: An even more critical issue during COVID-19 pandemic. DOI: 10.13181/mji.ed.205208.
- New proposed cut-off of waist circumference for central obesity as risk factor for diabetes mellitus: Evidence from the Indonesian Basic National Health Survey. DOI: 10.1371/journal.pone.0242417.
- Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia. DOI: 10.1038/s41598-020-75781-4.
- Curcumin Prevents Epithelial-to Mesenchymal Transition-Mediated Ovarian Cancer Progression through NRF2/ETBR/ET-1 Axis and Preserves Mitochondria Biogenesis in Kidney after Cisplatin Administration. DOI: 10.34172/apb.2022.014.
- The impact of Ramadan fasting on metabolic profile among type 2 diabetes mellitus patients: A meta-analysis. DOI: 10.1016/j.dsx.2020.07.033.
- Relationship of methyl mercaptan and hydrogen sulfide levels with tannerella forsythia quantity in periodontitis patients with halitosis and diabetes mellitus. DOI: 10.22159/ijap.2020.v12s2.OP-59.
- The impact of Ramadan fasting on glucose variability in type 2 diabetes mellitus patients on oral anti diabetic agents. DOI: 10.1371/journal.pone.0234443.
- Diagnosing metabolic syndrome in a multi-ethnic country: is an ethnic-specific cut-off point of waist circumference needed?. DOI: 10.1038/s41387-020-0123-8.
- Obesity as a predictor for a poor prognosis of COVID-19: A systematic review. DOI: 10.1016/j.dsx.2020.05.020.
- The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: A cross-sectional analysis of two population-based studies. DOI: 10.1186/s13098-019-0503-1.
- Helminth infections drive heterogeneity in human type 2 and regulatory cells. DOI: 10.1126/scitranslmed.aaw3703
- Penyakit Arteri Perifer dan Mortalitas Kardiovaskular pada Pasien Diabetes Melitus Tipe-2. DOI: 10.7454/jpdi.v6i2.299.
- Visceral adiposity index and lipid accumulation product as a predictor of type 2 diabetes mellitus: The Bogor cohort study of non-communicable diseases risk factors. DOI: 10.1016/j.diabres.2019.107798.
- A systematic review on the association between lipid accumulation product index and type 2 diabetes mellitus. DOI: 10.15605/jafes.034.01.04.
- Determinant of postprandial triglyceride levels in healthy young adults. DOI: 10.1016/j.dsx.2019.04.027.
- Visceral adiposity index as a predictor for type 2 diabetes mellitus in Asian population: A systematic review. DOI: 10.1016/j.dsx.2019.01.056
- Effect of Alfacalcidol on Inflammatory markers and T Cell Subsets in Elderly with Frailty Syndrome: a Double Blind Randomized Controlled Trial. PMID: 30333271
- Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet. DOI: 10.1038/s41598-018-25092-6
- Effect of anthelmintic treatment on leptin, adiponectin and leptin to adiponectin ratio: a randomized-controlled trial. DOI: 10.1038/nutd.2017.37
Collaborations
- Bioinformatics.
- Medical Technologies (MedTech).
- Center for Sport and Exercise Studies (SES).
- Stem Cell and Tissue Engineering (SCTE).
- Neuroscience and Brain Development (NBD).
- Human Nutrition Research Center (HNRC).
- Center of e-Learning
- Drug Development Research Center (DDRC).
- Primary Health Care Research and Innovation.
- Indonesia Museum Health and Medicine (I-Imuseum)
- Department of Cardiology-Vascular Medicine.
- Department of Community Medicine.
- Department of Internal Medicine.
- Department of Opthalmology.
- Department of Physiology.
- Department of Pharmacology and Therapeutics.
- Department of Parasitology.
- Nangapanda Community Research Center.
- Department of Nutrition.
- Department of Dermatology and Venereology.
- Department of Urology.
- Faculty of Dentistry.
- Faculty of Mathematics and Natural Sciences.
- Faculty of Public Health.
- Faculty of Engineering.
- Faculty of Pharmacy.
- RSUPN Cipto Mangunkusumo.
- RSJPD Harapan Kita.
- RSUP Fatmawati.
- RS Universitas Indonesia.
- Leiden University Medical Center.
- SUGAR-SPIN.
- Kobe University.
- Keio University.
- Jutendo University.
- Seoul National University.
- Queen Mary University.
- University of Shizuoka.
- University of South Australia.
- University of Tokyo.
- SEAMEO RECFON.
- National Institute of Health Research and Development, Ministry of Health Republic of Indonesia.
- Jakarta Provincial Health Office.
- Indonesian Society for Endocrinology (PERKENI).
- Association of Indonesian Obesity Studies (HISOBI).
- U45-ISHR Japanese Section, https://www.u45ishr.com/mci-and-global-fellows/
- Young International Cellular Senescence Association (yICSA) https://www.cellsenescence.info/yicsa.
- Bogor Institute of Agricultural.
- Indonesian Thyroid Association (INATA).
- National Research and Innovation Agency (BRIN).
Organization
