Metabolic Disorder, Cardiovascular, and Aging

Conducts research in the field of metabolic disorders, cardiovascular diseases, and physiology of aging, that can be translated into community and global health services, apart from the implementation in Dr. Cipto Mangunkusumo General Hospital and other teaching hospitals. The cluster is also expected to play a role in designation of medical education and health services policies. The research focus on the identification of basic phatomechanism and development of early detection methods including –but not limited to- biomarkers in the field of metabolic, cardiovascular and aging.

Research Projects

  • Ramadan fasting in type 2 diabetes*.
  • First-degree relatives of type 2 diabetes*.
  • Changes in microbiota profile and gut permeability on urbanization*
  • Gut microbiome on various spectrum of dysglycaemia.
  • Graves’ disease longitudinal study
  • Athlete’s heart#.
  • Telomere length in vascular aging.
  • Heart failure with preserved ejection fraction#.
  • Effect of sarcopenic obesity on type 2 diabetes.
  • Integration of Health Coaching and Diabetes Education in Type 2 Diabetes Mellitus Management at Primary Health Care* (ClinicalTrials.gov Identifier: NCT05090488).
  • COVID-19, aging and cardiometabolic risk factors (CARAMEL) study* (ClinicalTrials.gov Identifier: NCT04802044)
    The Bogor cohort study of non-communicable diseases*.
  • DiabetesLab Project (https://www.diabeteslab.id)

* datasets and biobanks are open for further analysis
# upcoming projects, open for collaboration

Publication

  • Treatment Adherence and Incidence of Coronary Heart Disease in Type 2 Diabetes Mellitus Patients. DOI: 10.21109/kesmas.v17i2.5453.
  • Adherence to the healthy lifestyle guideline in relation to the metabolic syndrome: Analyses from the 2013 and 2018 Indonesian national health surveys. DOI: 10.1016/j.pmedr.2022.101806.
  • Effects of Moringa oleifera in Two Independents Formulation and as Neuroprotective Agent Against Scopolamine-Induced Memory Impairment in Mice. DOI: 10.3389/fnut.2022.799127.
  • Three Years Survival and Factor Predicting Amputation or Mortality in Patients with High Risk for Diabetic Foot Ulcer in Fatmawati General Hospital, Jakarta. DOI: 10.1177/21501319211063707.
  • Characteristics of Diabetic Foot Ulcer Patients Pre- and During COVID-19 Pandemic: Lessons Learnt From a National Referral Hospital in Indonesia. DOI: 10.1177/21501319221089767.
  • Association Between Statin Use and Poor Outcomes in COVID-19 Patients with Diabetes Mellitus: A Systematic Review. DOI: 10.2174/1573399818666220209095056.
  • The role of Intestinal-Fatty Acid Binding Proteins and Chitinase-3-Like Protein 1 across the spectrum of dysglycemia. DOI: 10.1016/j.dsx.2021.102366.
  • Impact of diabetes mellitus on COVID-19 clinical symptoms and mortality: Jakarta’s COVID-19 epidemiological registry. DOI: 10.1016/j.pcd.2021.11.002.
  • Adherence to Treatment and Glycemic Control in Patients with Type 2 Diabetes Mellitus: A 4-Year Follow-up PTM Bogor Cohort Study, Indonesia. DOI: 10.2147/PPA.S318790.
  • Cardiovascular disease prediction model for Indonesian adult population with prediabetes and diabetes mellitus: The Bogor Cohort study of Noncommunicable Diseases Risk Factors. DOI: 10.1016/j.dsx.2021.102330.
  • A cross-sectional study on the telemedicine usage and glycemic status of diabetic patients during the COVID-19 pandemic. DOI: 10.13181/mji.oa.215558.
  • Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016). DOI: 10.1016/j.dsx.2021.102280.
  • Statin Mencegah Penurunan Kadar Hemoglobin dan Parameter Hematologi Lainnya pada Model Tikus Gagal Ginjal Eksperimental. DOI: 10.28932/jmh.v3i2.3332.
  • Non-vascular contributing factors of diabetic foot ulcer severity in national referral hospital of Indonesia. DOI: 10.1007/s40200-021-00827-x.
  • The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population. DOI: 10.1016/j.numecd.2021.05.012.
  • The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus. DOI: 10.1016/j.heliyon.2021.e06773.
  • Immunomodulatory effect of in vitro calcitriol in fit and frail elderly. DOI: 10.1016/j.intimp.2021.107737.
  • Puasa Ramadan dan Diabetes Melitus: Risiko, Manfaat dan Peluang Penelitian. DOI: 10.7454/jpdi.v8i1.576.
  • A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform. DOI: 10.12688/f1000research.28216.4.
  • The Impact of the Indonesian Chronic Disease Management Program (PROLANIS) on Metabolic Control and Renal Function of Type 2 Diabetes Mellitus Patients in Primary Care Setting. DOI: 10.1177/2150132720984409
  • Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients. DOI: 10.15283/ijsc20088.
  • High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis. DOI: 10.1016/j.diabres.2020.10856.
  • Burden of metabolic diseases in indonesia: An even more critical issue during COVID-19 pandemic. DOI: 10.13181/mji.ed.205208.
  • New proposed cut-off of waist circumference for central obesity as risk factor for diabetes mellitus: Evidence from the Indonesian Basic National Health Survey. DOI: 10.1371/journal.pone.0242417.
  • Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia. DOI: 10.1038/s41598-020-75781-4.
  • Curcumin Prevents Epithelial-to Mesenchymal Transition-Mediated Ovarian Cancer Progression through NRF2/ETBR/ET-1 Axis and Preserves Mitochondria Biogenesis in Kidney after Cisplatin Administration. DOI: 10.34172/apb.2022.014.
  • The impact of Ramadan fasting on metabolic profile among type 2 diabetes mellitus patients: A meta-analysis. DOI: 10.1016/j.dsx.2020.07.033.
  • Relationship of methyl mercaptan and hydrogen sulfide levels with tannerella forsythia quantity in periodontitis patients with halitosis and diabetes mellitus. DOI: 10.22159/ijap.2020.v12s2.OP-59.
  • The impact of Ramadan fasting on glucose variability in type 2 diabetes mellitus patients on oral anti diabetic agents. DOI: 10.1371/journal.pone.0234443.
  • Diagnosing metabolic syndrome in a multi-ethnic country: is an ethnic-specific cut-off point of waist circumference needed?. DOI: 10.1038/s41387-020-0123-8.
  • Obesity as a predictor for a poor prognosis of COVID-19: A systematic review. DOI: 10.1016/j.dsx.2020.05.020.
  • The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: A cross-sectional analysis of two population-based studies. DOI: 10.1186/s13098-019-0503-1.
  • Helminth infections drive heterogeneity in human type 2 and regulatory cells. DOI: 10.1126/scitranslmed.aaw3703
  • Effect of Alfacalcidol on Inflammatory markers and T Cell Subsets in Elderly with Frailty Syndrome: a Double Blind Randomized Controlled Trial. PMID: 30333271
  • Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet. DOI: 10.1038/s41598-018-25092-6
  • Effect of anthelmintic treatment on leptin, adiponectin and leptin to adiponectin ratio: a randomized-controlled trial. DOI: 10.1038/nutd.2017.37

Collaborations

  • Bioinformatics.
  • Medical Technologies (MedTech).
  • Center for Sport and Exercise Studies (SES).
  • Stem Cell and Tissue Engineering (SCTE).
  • Neuroscience and Brain Development (NBD).
  • Human Nutrition Research Center (HNRC).
  • Center of e-Learning
  • Department of Cardiology-Vascular Medicine.
  • Department of Community Medicine.
  • Department of Internal Medicine.
  • Department of Opthalmology.
  • Department of Physiology.
  • Department of Pharmacology and Therapeutics.
  • Department of Parasitology.
  • Nangapanda Community Research Center
  • Faculty of Dentistry.
  • Faculty of Mathematics and Natural Sciences.
  • Faculty of Public Health
  • RSUPN Cipto Mangunkusumo.
  • RSJPD Harapan Kita.
  • Leiden University Medical Center.
  • SUGAR-SPIN.
  • Kobe University.
  • SEAMEO RECFON.
  • National Institute of Health Research and Development, Ministry of Health Republic of Indonesia.
  • Jakarta Provincial Health Office.
  • Indonesian Society for Endocrinology (PERKENI).
  • Association of Indonesian Obesity Studies (HISOBI)

Organization