Human Cancer

HCRC dedicates itself to various aspects such as prevention, early detection, diagnosis and precision medicine. HCRC conducts research on diagnostic, risk factors, and treatment at the level of tissue, cellular, molecular and proteomics. Thus, HCRC is expected to contribute to early, more accurate identification of cancer or to determine more precise therapy to support the quality of life of patients and the community.

Research Topic

• Patient derived cancer models : spheroids/organoids in precision medicine.
• Liquid biopsies : Investigating and exploring circulating tumor cells; exploring less invasive biomarkers detections.
• Cancer genetics and biomarkers : gene fusion, expressions, and relations to clinical outcomes.
• Cancer drug discovery.
• Cancer screening and prevention strategies.

Ongoing Research Since 2022

• Biomarker studies for diagnostic, prognostic or therapeutic outcome predictors.
• Studies of genetic and epigenetic mutation profiles and their potential in identifying cancers due to hereditary factors.
• Cervical Cancer Prevention and HPV Vaccination Promotion for adolescent girls.
• Syndrome Profile Study with Microsatellite Instability (MSI)/ DNA Mismatch Repair (MMR) Examination in Young Colorectal Cancer Patients.
• WNT Pathway Activation Study and Angiogenesis.

Recent Publications

• Syahruddin E, Zaini J, Sembiring R, Baginta R, Fadhillah MR, Noor DR. TP53 and EGFR Mutational Status in Thymoma: A Genetic Sequencing Study. Asian Pac J Cancer Prev. 2022 Jan 1;23(1):109-114. doi: 10.31557/APJCP.2022.23.1.109. PMID: 35092378.
• Harahap AS, Sari DG, Stephanie M, Siswoyo AD, Zaid LSM, Kartini D, Ham MF, Tarigan TJE. Clinicopathological Profile of Thyroid Carcinoma in Young Patients: An Indonesian Single-Center Study. J Thyroid Res. 2022 Jan 11;2022:9944083. doi: 10.1155/2022/9944083. PMID: 35059180; PMCID: PMC8766174.
• Ramadhani HF, Annisa A, Tedjo A, Noor DR, Kusuma WA. Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19. Interdiscip Perspect Infect Dis. 2022 Apr 11;2022:3515001. doi: 10.1155/2022/3515001. PMID: 35422859; PMCID: PMC9002903.
• Asrini R, Ham MF, Asmarinah A, Harahap AS, Hardjolukito ESR. Expression of programmed cell death ligand-1 protein in germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma. Mol Clin Oncol. 2022 Feb;16(2):42. doi: 10.3892/mco.2021.2474. Epub 2021 Dec 21. PMID: 35003740; PMCID: PMC8739437.
• Husna M, Noor DR, Arum R, Qanita H, Abinawanto, Bowolaksono A, Julian ED, Dwiranti A. The Use of Patient-Derived Explant Cultures for Predicting Breast Cancer Cell Migration Potential In Vitro. 2022 May;49(5):146-150. doi: 10.55463/issn.1674-2974.49.5.16.
• Abdullah M, Sukartini N, Nursyirwan SA, Pribadi RR, Maulahela H, Utari AP, Muzellina VN, Wiraatmadja A, Renaldi K. Gut Microbiota Profiles in Early- and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future. Digestion. 2021;102(6):823-832. doi: 10.1159/000516689. Epub 2021 Aug 25. PMID: 34433172.
• Ariestine DA, Sari NK, Rinaldi I, Abdullah M. Quality of life in older survivors of non-Hodgkin’s lymphoma who received chemotherapy and related factors. J Geriatr Oncol. 2021 Mar;12(2):326-331. doi: 10.1016/j.jgo.2020.09.002. Epub 2020 Sep 30. PMID: 33008767.
• Pratomo IP, Noor DR, Kusmardi K, Rukmana A, Paramita RI, Erlina L, Fadilah F, Gayatri A, Fitriani M, Purnomo TTH, Ariane A, Heryanto R, Tedjo A. Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19. Int J Inflam. 2021 Aug 5;2021:1653392. doi: 10.1155/2021/1653392. PMID: 34367545; PMCID: PMC8346299.
• Abdullah M, Sudrajat DG, Muzellina VN, Kurniawan J, Rizka A, Utari AP, Pribadi RR, Idrus MF, Yusra Y, Meilany S, Surandy A, Shatri H, Rinaldi I, Pitoyo CW, Renaldi K. The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients. BMJ Open Gastroenterol. 2021 May;8(1):e000590. doi: 10.1136/bmjgast-2020-000590. PMID: 34011623; PMCID: PMC8136799.
• Soeroso NN, Ananda FR, Pradana A, Tarigan SP, Syahruddin E, Noor DR. The Absence of Mutations in the Exon 2 KRAS Gene in Several Ethnic Groups in North Sumatra May Not the Main Factor for Lung Cancer. Acta Inform Med. 2021 Jun;29(2):108-112. doi: 10.5455/aim.2021.29.108-112. PMID: 34584333; PMCID: PMC8443133.
• Kusmardi K, Wiyarta E, Rusdi NK, Maulana AM, Estuningtyas A, Sunaryo H. The potential of lunasin extract for the prevention of breast cancer progression by upregulating E-Cadherin and inhibiting ICAM-1. F1000Res. 2021 Sep 8;10:902. doi: 10.12688/f1000research.55385.1. PMID: 34691393; PMCID: PMC850622.
• Rustamadji P, Wiyarta E, Bethania KA, Kusmardi K. Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type. J Pathol Transl Med. 2021 Jul;55(4):271-278. doi: 10.4132/jptm.2021.04.26. Epub 2021 Jun 14. PMID: 34111909; PMCID: PMC8353139.
• Kusmardi K, Azzahra Baihaqi L, Estuningtyas A, Sahar N, Sunaryo H, Tedjo A. Ethanol Extract of Pomegranate (Punica granatum) Peel in Increasing the Expression of Caspase-3 in DSS-Induced Mice. Int J Inflam. 2021 Dec 2;2021:4919410. doi: 10.1155/2021/4919410. PMID: 34900217; PMCID: PMC8660243. 

Collaborators

• Dr. Cipto Mangunkusumo National Central Public Hospital (RSUPN).
• Female Cancer Programe, Leiden University.
• Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia.
• PT. PathGen Diagnostik Teknologi.
• Nottingham-Indonesia Collaboration for Clinical Research and Training (NICCRAT).
• Faculty of Medicine & Health Sciences, University of Nottingham.
• Faculty of Medicine, Airlangga University.
• CV. Abiramalab Indonesia.
• All India Institute of Medical Sciences.
• Graduate School of Pharmaceutical Sciences, Osaka University

Any Inquiries

• Email : hcrc.imeri@ui.ac.id