Infectious Disease and Immunology

Solve issues in infectious diseases, such as tuberculosis, malaria, HIV, leptospirosis, bacterial, and viral infections. With sophisticated equipment and comprehensive facilities. The research project is to develop a modern diagnostic for disease detection with high sensitivity and specificity, in particular for tuberculosis and leptospirosis. The cluster is aiming also at formulating a better treatment for infectious diseases by exploring the fundamental understanding of diseases, such as HIV with immunology non-responder patients.

Ongoing Research

• Dengue Research
  Study of the pathogenesis of Dengue Hemmorhagic Fever through Community based Study (DHF).
  Development of Dengue Detection Kit as an Academia-Industry Innovation Grant Joint Collaboration with PT Konimex.
  Development of Dengue Anti Viral Therapy.
• Malaria Research
  Community intervention to eliminate Malaria transmission by Plasmodium falciparum and Plasmodium vivax in endemic area.
  Manuscript in preparation: Failure of a Mass Screening and Treatment Campaign to Impact Malaria Transmission at a Site in West Timor, Indonesia: A Cluster-Randomised Trial.
• Tuberculosis Research
  Innate immune response of pulmonary tuberculosis patient and its correlation to Tuberculosis treatment.
  Improvement of TB nutritional state patient to reduce sputum conversion time.

Publication

• Asmarinah, Syauqy A, Umar LA, Lestari SW, Mansyur E, Hestiantoro A, Paradowszka-Dogan A. Sperm chromatin maturity and integrity correlated to zygote development in ICSI program. Syst Biol Reprod Med.
• Bao AM, Hestiantoro A, Van Someren EJ, Swaab DF, Zhou JN. Colocalization of corticotropin-releasing hormone and oestrogen receptor-alpha in the paraventricular nucleus of the hypothalamus in mood disorders. Brain.
• Bennett LR, Wiweko B, Hinting A, Adnyana IB, Pangestu M. Indonesian infertility patients’ health seeking behaviour and patterns of access to biomedical infertility care: an interviewer administered survey conducted in three clinics. Reprod Health.
• Bennett LR, Wiweko B, Bell L, Shafira N, Pangestu M, Adayana IB, Hinting A, Armstrong G. Reproductive knowledge and patient education needs among Indonesian women infertility patients attending three fertility clinics. Patients Educ Couns.
• Chua Y, Limpaphayom KK, Cheng B, Ho CM, Sumapradja K, Altomare C, Huang K. Genitourinary syndrome of menopause in five Asian countries: results from the Pan-Asian REVIVE survey. Climacteric.
• Hestiantoro A, Negoro YS, Afrita Y, Wiweko B, Sumapradja K, Natadisastra M. Anti-Müllerian hormone as a predictor of polycystic ovary syndrome treated with clomiphene citrate. Clin Exp Repro Med.
• Hestiantoro A, Swaab DF. Changes in estrogen receptor-alpha and -beta in the infundibular nucleus of the human hypothalamus are related to the occurrence of Alzheimer’s disease neuropathology. J Clin Endocriol Metabol.
• Hestiantoro A, Wiwie M, Shadrina A, Ibrahim N, Purba JS. FSH to estradiol ratio can be used as screening method for mild cognitive impairment in postmenopausal women. Climacteric.
• Kruger MC, Schollum LM, Kuhn-Sherlock B, Hestiantoro A, Wijanto P, Li-Yu J, Agdeppa I, Todd JM, Eastell R. The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia. Bone.
• Pratama G, Vaghjiani V, Tee JY, Liu YH, Chan J, Tan C, Murthi P, Gargett C, Manuelpillai U. Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications. Plos One.
• Swaab DF, Chung WC, Kruijver FP, Hofman MA, Hestiantoro A. Sex differences in the hypothalamus in the different stages of human life. Neurobiol Aging.
• Wiweko,B., Susanto, CA. The Effect of Metformin and Cinnamon on Serum Anti-Mullerian Hormone in Women Having PCOS: A Double-Blind, Randomized, Controlled Trial. Journal of Human Reproductive Science.
• Wiweko,B., Utami, P. Predictive value of sperm deoxyribonucleic acid (DNA) fragmentation index in male infertility. Basic Clinic Andrology.
• Wiweko B, Maidarti M, Priangga MD, Shafira N, Fernando D, Sumapraja K, Natadisastra M, Hestiantoro A. Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients. J Assist Reprod Genet.
• Wiweko B, Prawesti DM, Hestiantoro A, Sumapraja K, Natadisastra M, Baziad A. Chronological age vs biological age: an age-related normogram for antral follicle count, FSH and anti-Mullerian hormone. J Assist Reprod Genet.
• Wong PC, Qiao J, Ho C, Ramaraju GA, Wiweko B, Takehara Y, Nadkarni PV, Cheng LC, Chen HF, Suwajanakorn S, Vuong TN; Asia Pacific Fertility Advisory Group. Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective. Reprod Biomed Online.

Collaboration

• Biology Department, Faculty of Mathematics and Natural Sciences.
• SEAMEO RECFON.
  
• Computer Science Faculty.
  
• Human Nutrition Research Center.
  
• Department of Psychiatry.
  
• Department of Ear, Nose, and throat.
  
• Cluster of infectious disease and immunology.
  
• Giessen University.
  
• Kyoto University.