Stem Cell and Tissue Engineering

(SCTE) is conducting interdisciplinary and integrated research of stem cell & tissue engineering to answer global challenges in stem cell therapy, including Mesenchymal Stem Cells (MSCs) and Hematopoietic Stem Cells (HSCs). Several cutting edge stem cell technology for example liver organoids and microencapsulation of HSCs, genetically engineered MSCs for BMP-2 production, direct programming hepatocyte from skin fibroblast and Induced Pluripotent Stem Cells (iPSCs) are the on going research project at SCTE

In tissue engineering area, natural liver and bone scaffolds have been developed from decellularized animal and human tissues, combined with synthetic and natural polymers. In the field of cancer research, the cluster has initiated research for prospective adoptive NK cell immunotherapy.

Ongoing Research

  • Pengembangan Faktor Pertumbuhan BMP-2 dari Sel Punca Mesenkimal (Hibah Prioritas Riset Nasional 2021 an. Prof. Dr. dr. Ismail H. Dilogo, SpOT(K)).
  • Pengembangan Microencapsulation of Hematopoietic Stem Cells (HSCs) (Hibah Prioritas Riset Nasional 2021 an. Retno Wahyu Nurhayati, PhD).
  • Produksi Extracellular Vesicles (Evs) Bentuk Sediaan Cair dan Lyophilized dari Induced Pluripotent Stem Cells (IPSCs) Terinduksi sebagai Immunoterapi Regeneratif untuk Covid-19 Kritis dan Berat (Hibah Prioritas Riset Nasional 2021 an. dr. Radiana Dhewayani A, M.Biomed, PhD).
  • Pengembangan SHiNTA (Stem Cell Hepatic Intuitive Apparatus) (Hibah Prioritas Riset Nasional 2021 an. Dr. Akhmadu Muradi, SpB-K, PhD).
  • Rekayasa teknologi Cardiac Patch dari sel punca pluripoten kardiomiosit untuk atasi gagal jantung bayi akibat kardiomiopati dan penyakit jantung bawaan (Hibah Prioritas Riset Nasional 2021 an. Prof. Dr. dr. Mulyadi M Djer, Sp.A(K)).
  • Extracellular Vesicles (EVs) dari iPSCs Terinduksi Serum Pasien COVID-19 sebagai Immunoterapi Regeneratif untuk Pasien COVID-19 Berat dan Kritis (Hibah PDUPT an. Prof. Dr. dr. Ismail H. Dilogo, SpOT(K)).
  • Produksi Master Cell Sel Punca Hematopoietik untuk Skala Uji Klinis dan Kriopreservasi Stok (Hibah Swakelola Inovasi DISTP UI an. dr. Radiana Dhewayani A, M.Biomed, PhD).
  • Pengembangan Mikroenkapsulasi Sel Punca Hematopoietik Allogenik Berbasis Polimer Biokompatibel untuk Mencegah Penolakan Sistem Imun (Hibah Ristek-Brin 2021 an. Dr. dr. Rahyussalim, SpOT(K)).
  • Uji Stabilitas Produk Sel Punca Mesenkim Asaltali Pusat, Conditioned Medium Sediaan Beku dan Sediaan Beku Kering (Hibah Prioritas Riset Nasional 2021 an. Prof. dr. Jeanne A Pawitan, MS, PhD).
  • Pengembangan Matriks Alginat Kitosan sebagai Scaffold untuk Kultur 3-Dimensi Sel Keratinosit dan Sel Fibroblas Kulit (Hibah Program Pendanaan Perancangan dan Pengembangan Purwarupa (P5) 2022 an. Retno Wahyu Nurhayati, PhD).
  • Encapsulation of human mesenchymal stem cell-derived secretome using transfersome technology (Hibah Korea Institute of Science and Technology 2022 an. Muhammad Suhaeri, PhD).
  • Pengembangan Shinta (Stem Cell Hepatic Intuitive Apparatus) sebagai Sistem Dialisis Liver Extracorporeal Untuk Pasien End Stage Liver Disease (Hibah SHiNTA 2022 judulnya Riset Inovasi untuk Indonesia Maju (RIIM) 2022 an. dr. Chyntia Olivia Maurine Jasirwan, PhD, Sp.PD, SubSp.GEH)
Publication

Collaboration

Research and Education Center:

  • RSUPN Dr. Cipto Mangunkusumo.
  • PT. Kimia Farma (Persero), Tbk.
  • The University of Tokyo, Japan.
  • Pusat Jantung Nasional Harapan Kita.
  • Japan University of Yamanashi, Japan.
  • Leiden University Medical Center (LUMC), The Netherlands.
  • Kobe University, Japan.
  • Nangapanda Community Research Center.
  • Perkumpulan Ahli Bedah Orthopaedi Indonesia (PABOI).
  • Asosiasi Sel Punca Indonesia (ASPI).
    ProStem.
  • Perkumpulan Endokrinologi Indonesia (PERKENI).
  • Himpunan Studi Obesitas (HISOBI).
  • Persatuan Pembuluh Darah dan Limfe Indonesia (PPI).
  • Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI).

International Research Collaborator:

  • Prof. Lee Eng Hin, MD., FRCS(C)., FAMS.,
  • FRCS(Edin)., FRCS(Glas) – National University
  • Health System (NUHS) – Yong Lo Lin School of Medicine NUS.
  • Prof. James Goh, BSc., PhD – NUS Tissue Engineering Program (NUSTEP).
  • Prof. James Hui Hoi Po, MD., M.B.B.S., F.R.C.S. F.A.M.S – EP) – Tissue Engineering and Cell Therapy (TECT) NUH.
  • Prof Delvac Oceandy, MD, PhD – University of Manchester (UK).
  • Assoc. Prof. Tokunori Yamamoto, MD, PhD – Nagoya University (Japan).
  • Assist. Prof. Mime Kobayashi, PhD – Nara Institute of Science Technology (Japan).
  • Assoc. Prof. Noriaki Sasai, PhD – Nara Institute of Science Technology (Japan).
  • Assoc Prof. Yoshihiro Ojima, PhD – Osaka City University (Japan).
  • Prof. Toshiyuki Ikoma, PhD – Tokyo Institute of Technology (Japan).
  • Prof. Hanry Yu, PhD – National University of Singapore.
  • Ameer Mahmood, PhD – King Saud University (Saudi Arabia).
  • Prof. Shinji Sakai – Osaka University (Japan)